期刊
JOURNAL OF BIOPHOTONICS
卷 13, 期 2, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201960109
关键词
basal cell carcinoma; Raman imaging; Raman spectroscopy; rapid acquisition; skin cancer; tumor margin
资金
- Cancer Prevention and Research Institute of Texas [RP130702]
Spontaneous Raman micro-spectroscopy has been demonstrated great potential in delineating tumor margins; however, it is limited by slow acquisition speed. We describe a superpixel acquisition approach that can expedite acquisition between similar to x100 and x10 000, as compared to point-by-point scanning by trading off spatial resolution. We present the first demonstration of superpixel acquisition on rapid discrimination of basal cell carcinoma tumor from eight patients undergoing Mohs micrographic surgery. Results have been demonstrated high discriminant power for tumor vs normal skin based on the biochemical differences between nucleus, collagen, keratin and ceramide. We further perform raster-scanned superpixel Raman imaging on positive and negative margin samples. Our results indicate superpixel acquisition can facilitate the use of Raman microspectroscopy as a rapid and specific tool for tumor margin assessment.
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