期刊
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
卷 39, 期 4, 页码 1284-1294出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07391102.2020.1730971
关键词
Phospholipids; hydroperoxide; reactive oxygen and nitrogen species; oxidative stress; plasma medicine
资金
- Basic Science Research Program of the National Research Foundation of Korea (NRF) - Ministry of Education, Science, and Technology [2017R1C1B2003380]
The study revealed that lipid peroxidation causes lateral expansion and increased area of membrane systems, affecting membrane permeability. Nitrogen species have higher permeability through cell membranes compared to oxygen species, suggesting their importance in plasma-based treatments.
Biomembranes and lipid systems are rich in unsaturated lipid components and are subject to photo-induced lipid peroxidation. The peroxidized lipid products in cellular systems are known to affect the structural organization and function of the biomembrane. We employed molecular dynamics simulations to study the effects of phospholipid peroxidation on membrane properties and the permeability of different reactive species. The results suggest that when the lipids are peroxidized, the peroxide group moves toward the membrane surface, which causes the membrane system to expand laterally and increase in area. The permeability profile revealed that nitrogen species can easily permeate through the native and peroxidized system in comparison to oxygen species, suggesting its importance in plasma-based treatment. Thus, by breaching the energy barrier with lower energy, they can traverse the cell membrane and induce oxidative stress, which leads to apoptosis. Communicated by Ramaswamy H. Sarma
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