4.6 Article

The intracellular domain of homomeric glycine receptors modulates agonist efficacy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Mechanism of gating and partial agonist action in the glycine receptor

Jie Yu et al.

Summary: Using electrophysiology and cryo-EM reconstructions, this study investigated the mechanism of partial agonist action on neurotransmitter receptors, revealing new conformational states along the receptor reaction pathway. The results demonstrated that partial agonists can occupy closed channel states bound by agonists, affecting the receptor channel's open probability.
Article Multidisciplinary Sciences

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer

Duncan Laverty et al.

NATURE (2019)

Article Multidisciplinary Sciences

GABAA receptor signalling mechanisms revealed by structural pharmacology

Simonas Masiulis et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors

Cesar O. Lara et al.

ACS CHEMICAL NEUROSCIENCE (2019)

Article Chemistry, Analytical

Cross-Linking-Mass Spectrometry Studies of Cholesterol Interactions with Human alpha 1 Glycine Receptor

Nicholas A. Ferraro et al.

ANALYTICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Cryo-EM structure of 5-HT3A receptor in its resting conformation

Sandip Basak et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Conformational transitions of the serotonin 5-HT3 receptor

Lucie Polovinkin et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

Xin Huang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

Xin Huang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Article Multidisciplinary Sciences

Pentameric quaternary structure of the intracellular domain of serotonin type 3A receptors

Akash Pandhare et al.

SCIENTIFIC REPORTS (2016)

Review Neurosciences

The Intracellular Loop of the Glycine Receptor: It's not all about the Size

Georg Langlhofer et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

Xin Huang et al.

NATURE (2015)

Article Multidisciplinary Sciences

Glycine receptor mechanism elucidated by electron cryo-microscopy

Juan Du et al.

NATURE (2015)

Article Multidisciplinary Sciences

X-ray structure of the mouse serotonin 5-HT3 receptor

Gherici Hassaine et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Phosphorylation of α3 Glycine Receptors Induces a Conformational Change in the Glycine-Binding Site

Lu Han et al.

ACS CHEMICAL NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

The Minimum M3-M4 Loop Length of Neurotransmitter-activated Pentameric Receptors Is Critical for the Structural Integrity of Cytoplasmic Portals

Daniel T. Baptista-Hon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Multidisciplinary Sciences

Principles of activation and permeation in an anion-selective Cys-loop receptor

Ryan E. Hibbs et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Multifunctional Basic Motif in the Glycine Receptor Intracellular Domain Induces Subunit-specific Sorting

Nima Melzer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Characterization of the Effects of Charged Residues in the Intracellular Loop on Ion Permeation in α1 Glycine Receptor Channels

Jane E. Carland et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

The M4 transmembrane segment contributes to agonist efficacy differences between 1 and 3 glycine receptors

Xuebin Chen et al.

MOLECULAR MEMBRANE BIOLOGY (2009)

Article Multidisciplinary Sciences

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

Ricarda J. C. Hilf et al.

NATURE (2008)

Article Multidisciplinary Sciences

On the nature of partial agonism in the nicotinic receptor superfamily

Remigijus Lape et al.

NATURE (2008)

Article Multidisciplinary Sciences

A selective Gβγ-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol

Gonzalo E. Yevenes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Deciphering the structural framework of glycine receptor anchoring by gephyrin

EY Kim et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution

N Unwin

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Neurosciences

The activation mechanism of α1 homomeric glycine receptors

M Beato et al.

JOURNAL OF NEUROSCIENCE (2004)

Article Multidisciplinary Sciences

A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

SP Kelley et al.

NATURE (2003)

Article Biochemistry & Molecular Biology

A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor α1 subunit

S Sadtler et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Biology

The Croonian Lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission

N Unwin

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2000)