期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 23, 期 1, 页码 89-99出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2020.1724969
关键词
Aloin; barrier integrity; polyphosphate; vascular permeability
The study revealed that aloin can inhibit the inflammatory response induced by PolyP, which was confirmed in experiments, demonstrating its potential for treating systemic inflammatory diseases.
Human endothelial cells-derived polyphosphate (PolyP) is one of the pro-inflammatory mediators as suggested by the previous reports. Aloin is the major anthraquinone glycoside obtained from the Aloe species and exhibits anti-inflammatory and anti-oxidative activities. Aloin inhibits PolyP-mediated barrier disruption, the expressions of cell adhesion molecules, and adhesion/migration of leukocyte to HUVEC. PolyP-induced NF-kappa B activation and the productions of TNF-alpha and IL-6 were inhibited by aloin in HUVECs. These anti-inflammatory functions of aloin were confirmed in PolyP-injected mice. In conclusion, based on the anti-inflammatory effects of aloin in PolyP-mediated septic response, aloin has therapeutic potential for various systemic inflammatory diseases.
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