Chemical constituents from salt lake-derived Streptomyces sp. QHA10

Two new alkaloids (1,2) and one new enoic acid (3), together with three known piericidins (4-6), were isolated from the liquid fermentation of the salt lake derived Streptomyces sp. QHA10. The structures of 1-3 were elucidated based on extensive spectroscopic data (NMR, HRESIMS) as well as single-crystal X-ray diffraction. Compound 3 showed potential anti-inflammatory activity by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophages with the IC50 value of 24.5 mu M. [GRAPHICS] .

Automated summary

In this study, two new alkaloids and one new enoic acid were successfully isolated from the liquid fermentation of Streptomyces sp. QHA10 derived from a salt lake. The structures of these compounds were determined through extensive spectroscopic data analysis and X-ray diffraction. One of the new compounds exhibited potential anti-inflammatory activity by inhibiting nitric oxide production.