期刊
JOURNAL OF ANTIBIOTICS
卷 73, 期 4, 页码 211-223出版社
SPRINGERNATURE
DOI: 10.1038/s41429-019-0276-7
关键词
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资金
- JSPS KAKENHI [16H05095, 21310146]
- Grants-in-Aid for Scientific Research [16H05095] Funding Source: KAKEN
Eight new potentiators of antifungal amphotericin B (AmB) activity, phialotides A to H, were isolated from the fermentation broths of the rare fungus Pseudophialophora sp. BF-0158. The structures of phialotides were elucidated by spectroscopic analyses, including NMR and MS, and degradation studies. Phialotides were novel polyketide glycosides consisting of a 1,3-dimethylbut-1-ene (C-6-unit) repeating substructure and one to three hexopyranoses. None of the phialotides exhibited antifungal activity, whereas all potentiated AmB activity against several fungi. Phialotide F was the most effective potentiator of AmB activity against Candida albicans, with a decrease in the MIC from 0.50 to 0.016 mu g ml(-1) being observed in combination with phialotide F at 1.0 mu g ml(-1).
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