期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 72, 期 4, 页码 981-1017出版社
IOS PRESS
DOI: 10.3233/JAD-190863
关键词
Alzheimer's disease; amyloid-beta; genetic factors; neurodegeneration; oxidative stress; reactive oxygen species; tau
资金
- ZonMw Memorabel grant [733050304]
Alzheimer's disease is the most common neurodegenerative disorder that can cause dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress which interconnects with other processes such as amyloid-beta deposition, tau hyperphosphorylation, and tangle formation. This review discusses current thoughts on molecular mechanisms that may relate oxidative stress to Alzheimer's disease and identifies genetic factors observed from in vitro, in vivo, and clinical studies that may be associated with Alzheimer's disease-related oxidative stress.
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