期刊
BRITISH JOURNAL OF NUTRITION
卷 115, 期 12, 页码 2227-2235出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114516001628
关键词
Folate status; Pregnancy; Tobacco smoking; Hokkaido Study on Environment and Children's Health
资金
- Japanese Ministry of Health, Labour and Welfare [717L000103]
- Japan Society for the Promotion of Science (JSPS KAKENHI) [25253050]
- Grants-in-Aid for Scientific Research [16K19245, 15K15220] Funding Source: KAKEN
The International Clearinghouse for Birth Defects, Surveillance and Research reports a rise in the prevalence rate of spina bifida in Japan. We determined first-trimester folate status of Hokkaido women and identified potential predictors. Participants were 15 266 pregnant women of the Hokkaido Study on Environment and Children's Health Cohort. Data were extracted from self-reported questionnaires and biochemical assay results. Demographic determinants of low folate status were younger maternal age (adjusted OR (AOR) 1.48; 95% CI 1.32, 1.66), lower educational level (AOR 1.27; 95% CI 1.17, 1.39) and lower annual income (AOR 1.11; 95% CI 1.01, 1.22). Plasma cotinine concentrations of 1.19-65.21 nmol/l increased the risk of low folate status (AOR 1.20; 95% CI 1.10, 1.31) and concentrations > 65.21 nmol/l further increased the risk (AOR 1.91; 95% CI 1.70, 2.14). The most favourable predictor was use of folic acid (FA) supplements (AOR 0.19; 95% CI 0.17, 0.22). Certain socio-demographic factors influence folate status among pregnant Japanese women. Modifiable negative and positive predictors were active and passive tobacco smoking and use of FA supplements. Avoiding both active and passive tobacco smoking and using FA supplements could improve the folate status of Japanese women.
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