4.7 Article

Protective Effects of Sesamol on Systemic Inflammation and Cognitive Impairment in Aging Mice

期刊

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 10, 页码 3099-3111

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b07598

关键词

sesamol; aging; cognitive deficits; synaptic plasticity; neuroinflammation

资金

  1. National Key Research and Development Program of China [2016YFD0400601]
  2. National Natural Science Foundation of China [81803231, 81871118]
  3. Shaanxi Province Key Research and Development Project [2018NY-100]
  4. China postdoctoral science foundation [2016M602867, 2018T111104]
  5. Tang Cornell-China Scholars Program

向作者/读者索取更多资源

Sesamol, a lignan in sesame, possesses several bioactivities, such as antioxidation, anti-inflammation, and neuroprotective capability. In this study, the effects of sesamol on aging-caused cognitive defects are investigated. Twelve-month-old mice were treated with sesamol (0.1%, w/w) as dietary supplementation for 12 weeks. Behavioral tests revealed that sesamol improved aging-associated cognitive impairments. Sesamol decreased aging-induced oxidative stress via suppression of malondialdehyde production and increased antioxidant enzymes. Histological staining showed that sesamol treatment improved aging-induced neuronal damage and synaptic dysfunction in the hippocampus. Furthermore, sesamol significantly reduced aging-induced neuroinflammation by inhibiting the microglial overactivation and inflammatory cytokine expressions. Meanwhile, the accumulation of A beta(1- 42) was reduced by sesamol treatment. Moreover, sesamol protected the gut barrier integrity and reduced LPS release, which was highly associated with its beneficial effects on behavioral and inflammatory changes. In conclusion, our findings indicated that the use of sesamol is feasible in the treatment of aging-related diseases.

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