4.7 Article

Biocompatible Hydrogels Based on Food Gums with Tunable Physicochemical Properties as Scaffolds for Cell Culture

期刊

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 12, 页码 3770-3778

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b06120

关键词

composite hydrogel; food gums; polysaccharide; salecan; curdlan

资金

  1. National Natural Science Foundation of China [31800833, 21977081]
  2. Zhejiang Provincial Natural Science of Foundation of China [Z19H180001]
  3. Wenzhou Medical University [89218028]
  4. Wenzhou Institute of Biomaterials Engineering [WIBEZD2017001-03]
  5. Wenzhou Science and Technology Plan Project [Y20180071]
  6. Start-up Scientific Research Foundation of Wenzhou Medical University [KYQD20190513]
  7. Scientific Research Fund of the National Health Commission [wkj-zj-1707]

向作者/读者索取更多资源

Hydrogels composed of food gums have gained attention for future biomedical applications, such as targeted delivery and tissue engineering. For their translation to clinical utilization, reliable biocompatibility, sufficient mechanical performance, and tunable structure of polysaccharide hydrogels are required aspects. In this work, we report a unique hybrid polysaccharide hydrogel composed of salecan and curdlan, in which the former is a thickening agent and the latter serves as a network matrix. The physicochemical properties, such as mechanical strength, thermal stability, swelling, and morphology, of the developed composite hydrogel can be accurately modulated by varying the polysaccharide content. Importantly, cytotoxicity assays show the non-toxicity of this hybrid hydrogel. Furthermore, this hydrogel system can support cell proliferation, migration, and function. Altogether, our work proposes a new strategy to build a polysaccharide-constructed hydrogel scaffold, which holds much promise for tissue engineering in terms of cell engraftment, survival, proliferation, and function.

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