期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 5, 页码 1248-1256出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b05112
关键词
tyrosol; esters; gut microbiota; absorption; pharmacokinetics
资金
- National Natural Science Foundation of China [31901704, 31871759, 31801546]
- Project of Distinguished Professor of Liaoning Province [2015-153]
- Dalian Science and Technology Innovation Fund Project [2019J11CY005]
- China Postdoctoral Science Foundation [2017M621119]
Lipophenols are regarded as an emerging source of functional food ingredients. However, little is known about their in vivo digestion, absorption, and metabolism. Thus, the pharmacokinetic characteristics in rat and the gut microbial degradation of tyrosol acyl esters (TYr-Es) with fatty acids of C12:0, C18:0, and C18:2 were investigated for the first time. Major metabolites including tyrosol sulfate and tyrosol glucuronide, rather than the parent compounds, were detected in rat plasma after oral administration of TYr-Es. The increased plasma half-life (T-1/2) and mean residence time demonstrated that TYr-Es display a longer duration of action in vivo than TYr, potentially leading to higher oral bioavailability. TYr-Es could be hydrolyzed by the gut microbiota to free TYr, which may result in the appearance of the second absorption peak in pharmacokinetic profiles. Therefore, TYr-Es exhibit improved bioavailability compared to that of TYr because of their prolonged duration of action.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据