期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 6, 页码 1588-1595出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b06755
关键词
endostemonine; insecticidal activity; endophyte; secondary metabolite; Stemona sessilifolia
资金
- National Key RD Program [2018YFC1707900, 2018YFC1707000]
- Nature Science Foundation of Jiangsu Higher Education Institutions of China [19KJA180008]
- Outstanding Scientific and Technological Innovation Team Program of Jiangsu Higher Education Institutions
- Jiangsu Provincial Double Creation Program
- Priority Academic Program Development of Jiangsu Higher Education Institutions
The discovery of new, safe, and effective pesticides is one of the main means for modern crop protection and parasitic disease control. During the search for new insecticidal secondary metabolites from endophytes in Stemona sessilifolia (a traditional Chinese medicine with a long history as an insecticide), 10 new insecticidal endostemonines A-J (1-10) were identified from an endophytic Streptomyces sp. BS-1. Their structures were determined by comprehensive spectroscopic analysis. Endostemonines A-J represent the first reported naturally occurring pyrrole-2-carboxylic ester derivatives, which consisted of different fatty acid chains at the C-2 of pyrrole ring were produced by traditional Chinese medicine endophytic microbes. All new tested compounds exhibited strong lethal activity against Aphis gossypii (LC50 value range of 3.55-32.00 mg/L after 72 h). This research highlighted the discovery of pesticide natural products from insecticidal medicinal plant endophytes for the first time, paving a new pathway for the development of pest control.
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