期刊
INTERNATIONAL MATERIALS REVIEWS
卷 66, 期 2, 页码 77-113出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09506608.2020.1724705
关键词
Polymers; chitosan; poly(alpha hydroxy acids); poly(L-glutamic acid); microcarriers; microspheres; tissue engineering; review
资金
- National Natural Science Foundation of China [81701844, 51773057, 81701837, 51773113]
- National Experimental Teaching Demonstration Center of Chemical Engineering and Materials [2016(7)]
- Hunan Provincial Natural Science Foundation of China [2019JJ50163]
- IUC Program of Hunan Provincial Education Department [15CY004]
- Research Fund for the Doctoral Program of Hunan University of Science and Technology [E51897]
This article reviews important issues related to polymeric porous microcarriers for tissue engineering, including their properties, fabrication techniques, biomaterials, and applications in bone and cartilage tissue engineering.
For tissue regeneration or repair, a suitable temporary scaffold needs to be constructed for delivering regenerative cells to damaged or diseased tissue. Scaffold types are currently categorised into 3D monolithic scaffolds, hydrogels, and microcarriers. Among these scaffolds, microcarrier systems offer an attractive method for cell amplification and enhancement of phenotype expression, and they have emerged as powerful injectable carriers to repair and reconstruct irregular defects in tissues and organs. In this article, several important issues related to polymeric porous microcarriers for tissue engineering are reviewed. The properties of porous microcarriers, including surface chemistry, pore structure, typical particle size, and specific density, and the corresponding effects on cell cultures are discussed. The fabrication techniques and biomaterials investigated for porous microcarriers are summarised, and their advantages and disadvantages are outlined. Recent advancements in the application of porous microcarriers, including bone and cartilage tissue engineering, are also presented.
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