期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 174, 期 3, 页码 417-424出版社
WILEY-BLACKWELL
DOI: 10.1111/bjh.14073
关键词
Lymphoma; central nervous system; incidence; survival; human immunodeficiency virus; transplant
类别
资金
- Intramural Research Program of the National Cancer Institute
- Minneapolis Medical Research Foundation, Minneapolis, MN [HHSH250201000018C]
- Arbor Research Collaborative for Health in Ann Arbor, MI [HHSH234200537009C]
- SEER Program of the National Cancer Institute: California [HHSN261201000036C, HHSN261201000035C, HHSN261201000034C]
- SEER Program of the National Cancer Institute: Connecticut [HHSN261201000024C]
- SEER Program of the National Cancer Institute: Hawaii [HHSN261201 000037C, N01-PC-35137, N01-PC-35139]
- SEER Program of the National Cancer Institute: Iowa [HSN 261201000032C, N01-PC-35143]
- SEER Program of the National Cancer Institute: New Jersey [HHSN261201300021I, N01-PC-2013-00021]
- SEER Program of the National Cancer Institute: Seattle-Puget Sound [N01-PC-35142]
- SEER Program of the National Cancer Institute: Utah [HHSN2612013000171]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention [1U58 DP000807-01, U58 DP000848-04, 5U58DP003875-01, 5U58DP003883-03, U58DP12-1205 3919-03, 5U58DP003921-03, 5U58/DP003931-02, U58DP 003879, U58DP000832, 5U58DP000824-04]
- Massachusetts Cancer Prevention and Control Cooperative Agreement [5458DP003920]
- New Jersey (Memorandum of Agreement) [5-100-046-4220-496-6140]
- University of Utah
- Fred Hutchinson Cancer Research Center in Seattle, WA
It is suspected that primary central nervous system lymphoma (PCNSL) rates are increasing among immunocompetent people. We estimated PCNSL trends in incidence and survival among immunocompetent persons by excluding cases among human immunodeficiency virus (HIV)-infected persons and transplant recipients. PCNSL data were derived from 10 Surveillance, Epidemiology and End Results (SEER) cancer registries (1992-2011). HIV-infected cases had reported HIV infection or death due to HIV. Transplant recipient cases were estimated from the Transplant Cancer Match Study. We estimated PCNSL trends overall and among immunocompetent individuals, and survival by HIV status. A total of 4158 PCNSLs were diagnosed (36% HIV-infected; 09% transplant recipients). HIV prevalence in PCNSL cases declined from 641% (1992-1996) to 127% (2007-2011), while the prevalence of transplant recipients remained low. General population PCNSL rates were strongly influenced by immunosuppressed cases, particularly in 20-39 year-old men. Among immunocompetent people, PCNSL rates in men and women aged 65+ years increased significantly (17% and 16%/year), but remained stable in other age groups. Five-year survival was poor, particularly among HIV-infected cases (90%). Among HIV-uninfected cases, 5-year survival increased from 191% (1992-1994) to 301% (2004-2006). In summary, PCNSL rates have increased among immunocompetent elderly adults, but not in younger individuals. Survival remains poor for both HIV-infected and HIV-uninfected PCNSL patients.
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