期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 172, 期 6, 页码 909-913出版社
WILEY
DOI: 10.1111/bjh.13910
关键词
acute promyelocytic leukaemia; PML and RARA mutations; ATRA; ATO resistance; clonal selection
类别
资金
- Associazione Italiana per la Ricerca sul Cancro
- Associazione Italiana contro le Leucemie, Linfomi e Mieloma
Acute promyelocytic leukaemia (APL) is characterized by the PML/RARA fusion transcript. PML and RARA mutations have been shown to directly respond to arsenic trioxide (ATO) and all-trans retinoic (ATRA). We analysed the prevalence of PML mutations in 32 patients with de novo or therapy-related APL (t-APL; n=5), treated with ATO. We identified one ATO-resistant t-APL patient, who presented a PML A216T mutation in both the rearranged and unrearranged PML alleles, and two mutations in the rearranged RARA gene. In this patient, subclones with different PML and RARA mutations acquired clonal dominance during the disease course, probably leading to treatment resistance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据