期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 577, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.119093
关键词
Gellan gum; Methacrylation; In situ gelling; Mucoadhesion; Ocular drug delivery; Pilocarpine; Glaucoma; Wash out(50)
资金
- Ministry of Education and Science of the Republic of Kazakhstan [BR05234619, BR05236446]
- Researcher Links PostDoctoral Mobility Grant (British Council Newton - Al-Farabi Partnership Programme) [216046068]
- Al-Farabi Kazakh National University
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [823883]
- Ministry of Education and Science of the Republic of Tatarstan (Russia)
Gellan gum was chemically modified by the reaction with methacrylic anhydride to produce derivatives with 6, 14 and 49% methacrylation. The structure and substitution degrees of these derivatives were confirmed by H-1 NMR- and FTIR-spectroscopy. These derivatives are more hydrophobic compared to pristine gellan and form turbid solutions in water. In vitro study performed with formulations of sodium fluorescein containing gellan gum and its methacrylated derivatives indicated that methacrylation enhances their retention on bovine conjunctival mucosa. In vivo experiments with the formulations of pilocarpine hydrochloride containing gellan gum and methacrylated derivatives have demonstrated that all polymers enhance the drug effect significantly, but best performance is observed for the polysaccharide with 6% methacrylation.
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