期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 174, 期 1, 页码 16-29出版社
WILEY
DOI: 10.1111/bjh.14112
关键词
sickle cell anaemia; microparticle; extracellular vesicle; flow cytometry; biomarker
类别
资金
- National Heart and Lung Institute [UO1HL117659, 1UL1TR001111]
- Doris Duke Charitable Foundation [2013123]
Blood from patients with sickle cell disease contains microparticles (MP) derived from multiple cell sources, including red cells, platelets, monocytes and endothelial cells. MPs are of great interest because of their disease associations, their status as promising biomarkers, and the intercellular communications they mediate. To illustrate the likelihood of their relevance in sickle cell disease, we discuss the nature of MP, their profiling in sickle disease, some caveats relevant to their detection, their roles in supporting coagulation and the disparate influences they may exert upon the pathobiology of sickle cell disease.
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