期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 15, 期 -, 页码 1363-1372出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S238206
关键词
SELEX; EGFRvIII; GBM; therapy
资金
- National Natural Science Foundation of China [81871418, 81771484]
- Natural Science Foundation of Guangdong Province, China [2018A030313835]
- Undergraduate Innovation and Entrepreneurship Training Program of Southern Medical University [201912121234]
- Medical Scientific Research Foundation of Guangdong Province [B2019185]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_16R37]
- Guangzhou Science and Technology Project [201707020027]
- Scientific Research Startup Program of Southern Medical University [PY2018N084]
Purpose: In this study, we constructed novel brain-targeting complexes (U2-AuNP) by conjugating aptamer U2 to the gold nanoparticle (AuNPs) surface as a promising option for GBM therapy. Materials and Methods: The properties of the U2-AuNP complexes were thoroughly characterized. Then, we detected the in vitro effects of U2-AuNP in U87-EGFRvIII cell lines and the in vivo antitumor effects of U2-AuNP in GBM-bearing mice. Furthermore, we explored the inhibition mechanism of U2-AuNP in U87-EGFRvIII cell lines. Results: We found that U2-AuNP inhibits the proliferation and invasion of U87-EGFRvIII cell lines and prolongs the survival time of GBM-bearing mice. We found that U2-AuNP can inhibit the EGFR-related pathway and prevent DNA damage repair in GBM cells. Conclusion: These results reveal the promising potential of U2-AuNP as a drug candidate for targeted therapy in GBM.
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