期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms21020499
关键词
chitosan; conjugates; synthetic approach; antimicrobial activity; applications
资金
- National Key R&D Program of China [2018YFC0311305, 2019YFD0900705]
- Key Research and Development Program of Shandong Province [2018GHY115017, 2018GHY115008, 2019GHY112015]
- Qingdao Applied Basic Research Project [19-6-2-34-cg]
- Science and technology program of Nantong [MS120170234]
As a natural polysaccharide, chitosan possesses good biocompatibility, biodegradability and biosafety. Its hydroxyl and amino groups make it an ideal carrier material in the construction of polymer-drug conjugates. In recent years, various synthetic strategies have been used to couple chitosan with active substances to obtain conjugates with diverse structures and unique functions. In particular, chitosan conjugates with antimicrobial activity have shown great application prospects in the fields of medicine, food, and agriculture in recent years. Hence, we will place substantial emphasis on the synthetic approaches for preparing chitosan conjugates and their antimicrobial applications, which are not well summarized. Meanwhile, the challenges, limitations, and prospects of antimicrobial chitosan conjugates are described and discussed.
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