期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 93, 期 -, 页码 268-276出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2020.02.018
关键词
Virus; Antiviral drug; Drug discovery and development; Broad-spectrum antiviral agents; BSAAs
资金
- European Regional Development Fund
- Mobilitas Pluss Project [MOBTT39]
Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https://drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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