4.1 Article

The ontogeny of murine B-1a cells

期刊

INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 111, 期 5, 页码 622-627

出版社

SPRINGER JAPAN KK
DOI: 10.1007/s12185-019-02787-8

关键词

B-1a cells; Fetal derived; HSC-independent

资金

  1. NIAID [R01AI121197]

向作者/读者索取更多资源

It has been over 35 years since the discovery of a special subtype of B cells in mice. These IgM(+) B cells are named B-1 cells, whereas conventional B cells are referred to as B-2 cells. B-1 cells express Ly-1 (CD5) and CD11b antigen, which are usually expressed in T cells and myeloid cells, respectively, reside mainly in the peritoneal and pleural cavities, and secrete natural IgM antibodies in a T cell-independent manner. B-1 cells are further categorized into CD5(+) B-1a cells and CD5(-) B-1b cells. B-1 cells may develop through positive selection and secrete natural antibodies, including low-affinity-binding autoantibodies. Transplantation assays have revealed that the fetal liver, not the bone marrow (BM), is a major site for the production of B-1a cells, leading to the concept of a fetal origin for B-1a cells. This review introduces how the origin of B-1a cells has been explored, and describes the current state of knowledge gained through various approaches.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.1
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据