相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Repurposing antihypertensive drugs for the prevention of Alzheimer's disease: a Mendelian randomization study
Venexia M. Walker et al.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2020)
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle et al.
NATURE GENETICS (2019)
Opportunities and challenges for transcriptome-wide association studies
Michael Wainberg et al.
NATURE GENETICS (2019)
Human Genetics and Drug Development
Michael V. Holmes
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization
Kurt Taylor et al.
GENOME MEDICINE (2019)
Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder
Helena A. Gaspar et al.
TRANSLATIONAL PSYCHIATRY (2019)
A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice
Shuyu Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Lowering of Amyloid-Beta by β-Secretase Inhibitors - Some Informative Failures
David S. Knopman
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
Phuong A. Nguyen et al.
NATURE COMMUNICATIONS (2019)
A genetics-led approach defines the drug target landscape of 30 immune-related traits
Hai Fang et al.
NATURE GENETICS (2019)
Evaluating the potential role of pleiotropy in Mendelian randomization studies
Gibran Hemani et al.
HUMAN MOLECULAR GENETICS (2018)
Tocilizumab in the treatment of myocardial infarction
Matthew B. Carroll
MODERN RHEUMATOLOGY (2018)
N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease
Elena V. Kugaevskaya et al.
SCIENTIFIC REPORTS (2018)
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Neil M. Davies et al.
BMJ-BRITISH MEDICAL JOURNAL (2018)
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Neil M. Davies et al.
BMJ-BRITISH MEDICAL JOURNAL (2018)
Genomic atlas of the human plasma proteome
Benjamin B. Sun et al.
NATURE (2018)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Evangelos Evangelou et al.
NATURE GENETICS (2018)
Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy A Phenome-Wide Association Study
Tianxi Cai et al.
JAMA CARDIOLOGY (2018)
Questions concerning the role of amyloid-beta in the definition, aetiology and diagnosis of Alzheimer's disease
Gary P. Morris et al.
ACTA NEUROPATHOLOGICA (2018)
Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study
Blanaid M. Hicks et al.
BMJ-BRITISH MEDICAL JOURNAL (2018)
A perspective on multi-target drug discovery and design for complex diseases
Rona R. Ramsay et al.
CLINICAL AND TRANSLATIONAL MEDICINE (2018)
Comprehension of Top 200 Prescribed Drugs in the US as a Resource for Pharmacy Teaching, Training and Practice
Andrea V. Fuentes et al.
PHARMACY (2018)
Why do trials for Alzheimer's disease drugs keep failing? A discontinued drug perspective for 2010-2015
Dev Mehta et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2017)
Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities
Venexia M. Walker et al.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2017)
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality
Michael V. Holmes et al.
NATURE REVIEWS CARDIOLOGY (2017)
Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis
Susanna C. Larsson et al.
BMJ-BRITISH MEDICAL JOURNAL (2017)
Orienting the causal relationship between imprecisely measured traits using GWAS summary data
Gibran Hemani et al.
PLOS GENETICS (2017)
Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis
Susanna C. Larsson et al.
BMJ-BRITISH MEDICAL JOURNAL (2017)
Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes
Brian A. Ference et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
Jack Bowden et al.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2015)
Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
Mary D. Fortune et al.
NATURE GENETICS (2015)
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
Soren D. Ostergaard et al.
PLOS MEDICINE (2015)
Mendelian randomization of blood lipids for coronary heart disease
Michael V. Holmes et al.
EUROPEAN HEART JOURNAL (2015)
Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline
Kenneth E. Bernstein et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
The association of angiotensin-converting enzyme with biomarkers for Alzheimer's disease
Hadassa M. Jochemsen et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation
John S. K. Kauwe et al.
PLOS GENETICS (2014)
Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
Claudia Giambartolomei et al.
PLOS GENETICS (2014)
Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia
Yang Gao et al.
BMJ OPEN (2013)
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
Daniel I. Swerdlow et al.
LANCET (2012)
Amyloid β-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor
ML Hemming et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)