期刊
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
卷 25, 期 4, 页码 531-540出版社
SPRINGER JAPAN KK
DOI: 10.1007/s10147-019-01593-w
关键词
Colorectal cancer; Gastrointestinal stromal tumor; C-trough; Regorafenib; Therapeutic drug monitoring
类别
Background Regorafenib is a multiple tyrosine kinase inhibitor, and the use of this drug is approved for the treatment of cancers that are resistant to chemotherapy, which include advanced colorectal cancer, gastrointestinal stromal tumor, and hepatocellular carcinoma. However, the drug causes adverse events, including skin toxicities that require dose modification in approximately 75% of cases. At present, the blood concentration of regorafenib is not assessed in clinical settings; thus, we recently developed a method that can assess the blood concentration of the drug using high-performance liquid chromatography. Methods We measured the trough blood concentrations (C-trough) of regorafenib and its metabolites (M2 and M5) in 14 and 4 patients with advanced colorectal cancer and gastrointestinal stromal tumor, respectively, using high-performance liquid chromatography. Then, the correlation between the C-trough and therapeutic outcomes of regorafenib was analyzed. Results In patients who were receiving regorafenib 40-160 mg/day, the C-trough values of regorafenib, M2, and M5 were 318-9467, 34-3594, and 38-3796 ng/mL, respectively. The difference in the values was significant. Although the specific factors influencing this difference were not elucidated, the C-trough of regorafenib was extremely lower in some patients, even though the drug was administered at a standard dose, which may explain the lower response rate. Moreover, the C-trough value of M5 was significantly correlated to the incidence of skin toxicities, which is the most frequent cause of dose modification. Conclusions The use of regorafenib may not be suitable in patients with a low C-trough value. To prevent skin toxicities, the C-trough value of M5 should be monitored.
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