期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 143, 期 -, 页码 265-272出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.12.050
关键词
Starch-based hydrogel; Diels-Alder; Cellulose nanocrystals
资金
- Basque Government [IT-776-13, KK2018/00050]
- University of the Basque Country [PIF-G-003-2015]
Starch-based nanocomposite hydrogels were successfully prepared by the Diels-Alder click cross-linking reaction between furan-functionalized starch derivative and a water-soluble tetrafunctional maleimide compound, adding cellulose nanocrystals (CNC) as nanoreinforcement. The effect of increasing the CNC content on rheological and swelling properties as well as on the morphology of the hydrogels was analyzed. Besides, in order to evaluate the applicability of the as-prepared hydrogels as delivery systems, drug release measurements and in vitro cytotoxicity assays were also performed. It was found that the prepared nanocomposite hydrogels presented higher stiffness as the CNC content increased. The incorporation of the nanocrystals modified the internal porous microstructure of the hydrogels, affecting consequently both the swelling capacity and the drug-delivery kinetics. Moreover, the prepared nanocomposite hydrogels showed non-toxic behavior, demonstrating their potential applicability in the biomedical field, especially as sustained drug delivery systems. (C) 2019 Elsevier B.V. All rights reserved.
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