4.5 Article

Host miR-148 regulates a macrophage-mediated immune response during Schistosoma japonicum infection

期刊

INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 49, 期 13-14, 页码 993-997

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2019.08.002

关键词

Extracellular vesicle; microRNA cargo; miR-148a; Schistosoma japonicum; Macrophage

资金

  1. National Natural Science Foundation of China [31672550, 31472187]
  2. Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences

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Extracellular vesicles are critical regulators of host-parasite interactions. We previously demonstrated that Schistosoma japonicum EVs contain a remarkably high abundance of host miR-148a. Here, we characterised the abundance of miR-148a in circulation, in peripheral immune cells, and in plasma EVs of S. japonicum-infected mice. The results suggested the high abundance of miR-148a in macrophages to be likely linked to S. japonicum EVs. Additionally, miR-148a was found to target PTEN through the PI3K/AKT pathway to regulate cytokine production in macrophages. Consequently, our findings suggest that high abundance of miR-148a in macrophages may be associated with S. japonicum EVs, and regulate the host immune response during schistosome infection. (C) 2019 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

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