期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 78, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2019.106115
关键词
Lactobacillus rhamnosus CRL1505; Influenza virus; Respiratory immunity; Adaptive immune response; Immunobiotics; Vaccination
资金
- ANPCyT-FONCyT [PICT-2013-3219, PICT-2016-0410]
- Japan Society for the Promotion of Science (JSPS) [19H00965]
- project of NARO Bio-oriented Technology Research Advancement Institution (Research Program on development of innovation technology) [01002A]
- Ministry of Education, Culture, Science, Sports and Technology (MEXT) of Japan [16H06429, 16K21723, 16H06435]
- JSPS [18F18081]
- JSPS Core-to-Core Program Advanced Research Networks Establishment of international agricultural immunology research-core for a quantum improvement in food safety
The nasal priming with Lactobacillus rhamnosus CRL1505 modulates the respiratory antiviral innate immune response and improves protection against influenza virus (IFV) challenge in mice. However, the potential beneficial effect of the CRL1505 strain on the adaptive immune response triggered by IFV infection or vaccination was not evaluated before. In this work, we demonstrated that nasally administered L. rhamnosus CRL1505 is able to improve both the humoral and cellular adaptive immune responses induced by IFV infection or vaccination. Higher levels of IFV-specific IgA and IgG as well as IFN-gamma were found in the serum and the respiratory tract of CRL1505-treated mice after IFV challenge. Lactobacilli treated mice also showed reduced concentrations of IL-17 and improved levels of IL-10 during IFV infection. The differential balance of inflammatory and regulatory cytokines induced by L. rhamnosus CRL1505 contributed to the protection against IFV by favoring an effective effector immune response without inducing inflammatory-mediated lung damage. The optimal immunomodulatory effect of the CRL1505 strain was achieved with viable bacteria. However, non-viable L. rhamnosus CRL1505 was also efficient in improving the adaptive immune responses generated by IFV challenges and therefore, emerged as an interesting alternative for vaccination of immunocompromised hosts. Similar to other immunomodulatory properties of lactobacilli, it was shown here that the adjuvant effect in the context of IFV vaccination was a strain dependent ability, since differences were found when L. rhamnosus CRL1505 and the immunomodulatory strain L. rhamnosus IBL027 were compared. This investigation represents a thorough exploration of the role of immunobiotic lactobacilli in improving humoral and cellular adaptive immune responses against IFV in the context of both infection and vaccination.
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