期刊
INTERNAL MEDICINE
卷 59, 期 1, 页码 77-81出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.3440-19
关键词
Wilson disease; liver biopsy; hepatic copper content
A 37-year-old Wilson disease patient treated with D-penicillamine visited our hospital for the evaluation of his liver function. Laboratory data showed a low serum copper level and ceruloplasmin. The ratio of urinary copper to urinary creatinine in a spot urinary analysis after 4 days' cessation of D-penicillamine was under 0.1. We concluded that the copper chelation was excessive and changed D-penicillamine to zinc acetate. However, his liver function test results did not normalize. We performed a liver biopsy and discovered a high copper content. The liver dysfunction was improved after resuming chelating therapy. Accurate measurement of the hepatic copper content via a biopsy is important for the adequate management of this disease.
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