期刊
INORGANICA CHIMICA ACTA
卷 499, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2019.119197
关键词
Neuromedin C; ATCUN motif; Binding constants; Fluorescence spectroscopy
资金
- Spain's Ministry of Economy and Competitiveness (MINECO)
- European Fund for Regional Development [CTQ2014-55835-R]
- MINECO [FPU14/01131]
- European Social Fund
- SOIB
- garantia juvenil
- Ministry of employment and social security
Neuromedin C (NMC) is an endogenous bombesine-like peptide that is present mainly in the central nervous system (CNS) and the gastrointestinal tract. In addition to its biological function as a neuropeptide, NMC acts as a growth factor for some tumours and plays a major role in transition metal homeostasis in the CNS. In this work, we determined the binding constants and main thermodynamic parameters for the complexes of NMC with Cu2+, Ni2+ and Co2+ ions. The binding constants obtained were consistent with the Irving-Williams series, where the affinity for transition metal cations increases across the periodic table. All NMC complexes had a positive enthalpy (Delta H > 0), which is consistent with an entropy-driven process. The affinity of NMC for Cu2+ and Ni2+ was similar to that of other peptides also containing the ATCUN motif. However, the low concentrations of NMC in serum suggest that the peptide is unlikely to play a biological role in metal homeostasis in the CNS or the gastrointestinal tract.
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