期刊
INFLAMMATORY BOWEL DISEASES
卷 26, 期 11, 页码 1722-1729出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ibd/izz308
关键词
ulcerative colitis; clinical relapse; histology; basal plasmacytosis; Geboes score
资金
- Canadian Institutes of Health Research (CIHR)/Canadian Association of Gastroenterology (CAG)/AbbVie IBD Fellowship
- Gale and Graham Wright Chair in Digestive Diseases at Mount Sinai Hospital
- Crohn's and Colitis Canada (CCFC)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [DK-062423]
Background: In ulcerative colitis (UC) patients who have achieved mucosal healing, active microscopic colonic mucosal inflammation is commonly observed. We aimed to assess the association between histological activity and disease relapse in endoscopically quiescent UC. Methods: Ulcerative colitis patients with endoscopically quiescent disease and >= 12 months of follow-up were included. Biopsies were reviewed for the presence of basal plasmacytosis (BPC) and active histological inflammation, defined as a Geboes score (GS) >= 3.2. Primary outcome measures were disease relapse at 18 months and time to first relapse after index colonoscopy. Results: Seventy-six UC patients (51% male; mean age, 38.6 years; median follow-up [range], 75.2 [2-118] months) were included. Sixty-two percent had an endoscopic Mayo score of 0 at index colonoscopy. Basal plasmacytosis was present in 46% and active histological inflammation in 30% of subjects. Presence of BPC was associated with a significantly shorter time to disease relapse (P = 0.01). Active histological inflammation was significantly associated with clinical relapse at 18 months (P = 0.0005) and shorter time to clinical relapse (P = 0.0006). Multivariate analysis demonstrated active histological inflammation to be independently associated with clinical relapse at 18 months and time to clinical relapse. Conclusions: In endoscopically quiescent UC, active histological inflammation and the presence of BPC are adjunctive histological markers associated with increased likelihood of disease relapse. Although prospective studies are required, the presence of these histological markers should be a factor considered when making therapeutic decisions in UC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据