期刊
BRITISH JOURNAL OF CANCER
卷 116, 期 2, 页码 156-162出版社
SPRINGERNATURE
DOI: 10.1038/bjc.2016.398
关键词
anal cancer; chemoradiotherapy; HPV; squamous cell carcinoma of the anus; human papilloma virus; biomarkers
类别
资金
- Cancer Research UK [19121, 16463] Funding Source: researchfish
- National Institute for Health Research [ACF-2015-02-004] Funding Source: researchfish
Squamous cell carcinomas of the anus and anal canal represent a model of a cancer and perhaps the first where level 1 evidence supported primary chemoradiotherapy (CRT) in treating locoregional disease with curative intent. The majority of tumours are associated with infection with oncogenic subtypes of human papilloma virus and this plays a significant role in their sensitivity to treatment. However, not all tumours are cured with CRT and there remain opportunities to improve outcomes in terms of oncological control and also reducing late toxicities. Understanding the biology of ASCC promises to allow a more personalised approach to treatment, with the development and validation of a range of biomarkers and associated techniques that are the focus of this review.
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