期刊
BRITISH JOURNAL OF CANCER
卷 115, 期 9, 页码 1017-1023出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2016.312
关键词
integrins; focal adhesion kinase; endosomes; exosomes; tumour stroma; growth factor receptors; cancer stem cells
类别
资金
- Academy of Finland
- ERC Consolidator Grant
- Sigrid Juselius Foundation
- Cancer Society of Finland
Cancer is a complex disease and progresses within a dynamically evolving extracellular matrix that controls virtually every aspect of the tumour and tumour-associated cells. Interactions with the extracellular microenvironment are predominately mediated by a family of cell-surface transmembrane receptors called integrins. Integrin-matrix engagement leads to the formation of adhesion plaques, consisting of signalling and adaptor proteins, at the plasma membrane that link the extracellular matrix to the regulation of the cell cytoskeleton. In this review, we will highlight exciting data that identify new roles for integrins and integrin-dependent signalling in cancer away from the plasma membrane, discuss the implications of integrin-dependent regulation of Met and ErbB2 growth factor receptors and highlight the role of specific integrins in different stages of cancer development including maintenance of cancer stem cells.
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