期刊
BRITISH JOURNAL OF CANCER
卷 115, 期 3, 页码 273-280出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2016.189
关键词
colorectal cancer; microbiota; biofilms; pattern recognition receptors; inflammasomes; inflammation
类别
The gut microbiota has been hailed as an accessory organ, with functions critical to the host including dietary metabolic activities and assistance in the development of a proper functioning immune system. However, an aberrant microbiota (dysbiosis) may influence disease processes such as colorectal cancer. In this review, we discuss recent advances in our understanding of the contributions of the microbiota to prevention, initiation/progression, and treatment of colorectal cancer, with a major focus on biofilms and the antimicrobial and antitumoural immune response.
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