期刊
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
卷 40, 期 1, 页码 15-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2019.09.010
关键词
Allergy; Allergen immunotherapy; AIT; Adjuvants; Allergoids; Recombinant allergen peptides; Active immunization; Passive immunization
资金
- Hungarian Pediatric Oncology Network
- Swiss National Science Foundation
Increasing safety while maintaining or even augmenting efficiency are the main goals of research for novel vaccine development and improvement of treatment schemes in allergen immunotherapy (AIT). To increase the efficacy of AIT, allergens have been coupled to innate immunostimulatory substances and new adjuvants have been introduced. Allergens have been modified to increase their uptake and presentation. Hypoallergenic molecules have been developed to improve the safety profile of the vaccines. Administration of recombinant IgG4 antibodies is a new, quick, passive immunization strategy with remarkable efficiency. Results of some current investigations aiming at further improvement of AIT vaccines have been summarized.
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