期刊
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
卷 40, 期 1, 页码 1-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2019.09.009
关键词
Allergy; Aeroallergen; Allergen immunotherapy; Subcutaneous allergen immunotherapy; Sublingual allergen immunotherapy; Treg cells; Breg cells; Innate lymphoid cells
资金
- Hungarian Pediatric Oncology Network
- Swiss National Science Foundation
Allergen immunotherapy (AIT) is considered to be the only treatment option with the promise of healing and induction of long-lasting allergen tolerance, persisting even after discontinuation of therapy. Despite a more than 100-year-long history, still only a minority of patients are being treated with AIT. Substantial developments took place in the last decade to overcome problems in standardization, efficacy, safety, high costs, long duration of treatment; and new guidelines have also been implemented. Major advancements in the understanding of AIT mechanisms with the focus on recent findings of subcutaneous and sublingual AIT have been summarized.
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