期刊
BRITISH JOURNAL OF CANCER
卷 114, 期 6, 页码 605-611出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2016.36
关键词
leukaemia; histone deacetylases; HDACi; cancer stem cells; APL; epigenetics
类别
资金
- AIRC (Italian Association for Cancer Research)
- FIRC (Italian Foundation for Cancer Research)
- Epigen Flagship Project
- European Community (4D Cell Fate and Blueprint)
- Fondazione Veronesi
Histone deacetylases (HDACs) are a key component of the epigenetic machinery regulating gene expression, and behave as oncogenes in several cancer types, spurring the development of HDAC inhibitors (HDACi) as anticancer drugs. This review discusses new results regarding the role of HDACs in cancer and the effect of HDACi on tumour cells, focusing on haematological malignancies, particularly acute myeloid leukaemia. Histone deacetylases may have opposite roles at different stages of tumour progression and in different tumour cell sub-populations (cancer stem cells), highlighting the importance of investigating these aspects for further improving the clinical use of HDACi in treating cancer.
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