期刊
BRITISH JOURNAL OF CANCER
卷 115, 期 1, 页码 108-114出版社
SPRINGERNATURE
DOI: 10.1038/bjc.2016.157
关键词
AMORIS; cholesterol; diabetes; epidemiology; glucose; meningioma
类别
资金
- National Cancer Institute, National Institutes of Health [R01CA122163]
Background: Although meningioma is a benign tumour, it may cause significant morbidity. Obesity and diabetes are positively associated with meningioma. To evaluate the potential effects of obesity-related prediagnostic glucose, triglycerides and cholesterol on meningioma and of prediagnostic meningioma on these biomarkers, we conducted a cohort study. Methods: We identified 41 355 individuals in the Apolipoprotein MOrtality RISk cohort with values for these biomarkers within 15 years before meningioma diagnosis, death, migration or the end of follow-up. We then estimated hazard ratios (HRs) and their interactions with time and age using Cox regression. Results: Meningioma was diagnosed in 181 women and 115 men whose median follow-up time was 7 years. Fasting serum glucose level was inversely related to meningioma among women (P-trend = 0.0006) but not men (P-trend = 0.24). Prediagnostic diabetes was inversely related to meningioma in both sexes combined (HR = 0.45, 95% confidence interval (CI) 0.29-0.71), as was serum cholesterol within the year before diagnosis (HR = 0.50, 95% CI 0.34-0.72). Conclusions: Paradoxically, hyperglycaemia is inversely associated with meningioma in women. This finding does not necessarily negate the positive role of obesity or diabetes in meningioma development; rather, it may indicate that their effects depend on the stage of development. Furthermore, the prediagnostic tumour may reduce serum cholesterol levels.
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