期刊
IEEE TRANSACTIONS ON MEDICAL IMAGING
卷 38, 期 12, 页码 2875-2882出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2019.2916326
关键词
High-resolution imaging; positron emission tomography; wobbling; zooming; convertible
类别
资金
- Converging Research Center Program [2013K000343]
- Basic Science Research Program [NRF-2015R1C1A1A 02037686]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2017M3C7A1049026]
- National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2016R1D1A1B03930854]
- National Research Foundation of Korea [2017M3C7A1049026] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Demands for in-vivo human molecular imaging with high resolution and high sensitivity in positron emission tomography (PET) require several new design formulae. A classical problem of the PET design, however, was the trade-off between sensitivity and resolution. To satisfy both requirements, the brain-body convertible PET with wobbling and zooming is proposed. The features of this new proposed system are wobble sampling for high-resolution imaging and zooming mode for high sensitivity, especially for the brain dedicated imaging. For the high resolution, wobbling with a linear interpolation and line spread function (LSF) deconvolution reconstruction algorithm was introduced. The result of the proposed system provided resolution up to 1.56 mm full width at half maximum (FWHM) in the brain mode and resulting in the detector-to-resolution ratio (DRR) was 2.47. For both brain phantom and in-vivo rat brain imaging, the proposed system demonstrated superior image quality compared with the commercial PET systems. The newly designed PET with wobbling and zooming also demonstrated the possibility of developing practically usable high-resolution human brain PET-MRI fusion system, especially for the neuroscience research.
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