期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 67, 期 1, 页码 27-37出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2019.2907556
关键词
Lenses; Transducers; Acoustics; Ultrasonic imaging; Focusing; Numerical simulation; Phased arrays; Acoustic lens; transcranial ultrasound; therapeutic ultrasound
资金
- Bettencourt Schueller Foundation
- Agence Nationale de la Recherche under the program Future Investments [ANR-10-EQPX-15]
- Inserm Technology Research Accelerator (Inserm ART) in Biomedical Ultrasound, Paris, France
For successful brain therapy, transcranial focused ultrasound must compensate for the time shifts induced locally by the skull. The patient-specific phase profile is currently generated by multi-element arrays which, over time, have tended toward increasing element count. We recently introduced a new approach, consisting of a single-element transducer coupled to an acoustic lens of controlled thickness. By adjusting the local thickness of the lens, we were able to induce phase differences which compensated those induced by the skull. Nevertheless, such an approach suffers from an apparent limitation: the lens is a priori designed for one specific target. In this paper, we demonstrate the possibility of taking advantage of the isoplanatic angle of the aberrating skull in order to steer the focus by mechanically moving the transduceracoustic lens pair around its initial focusing position. This study, conducted on three human skull samples, demonstrates that tilting of the transducer with the lens restores a single -3 dB focal volume at 914 kHz for a steering up to 11 mm in the transverse direction, and 10 mm in the longitudinal direction, around the initial focal region.
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