期刊
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
卷 13, 期 6, 页码 1792-1807出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBCAS.2019.2951298
关键词
Age-related Macular Degeneration (AMD); Optogenetics; Photostimulator; Retinal Degeneration; Retinitis Pigmentosa (RP); Retinal Prosthesis; Vision Restoration
资金
- Natural Science and Engineering Research Council of Canada
- Microsystems Strategic Alliance of Quebec
- Canada Research Chair in Smart Medical Devices
- Canada Research Chair (Tier II) in Neuronal Circuits of Vision
Optogenetic strategies for vision restoration involve photosensitizing surviving retinal neurons following retinal degeneration, using emerging optogenetic techniques. This approach opens the door to a minimally-invasive retinal vision restoration approach. Moreover, light stimulation has the potential to offer better spatial and temporal resolution than conventional retinal electrical prosthetics. Although proof-of-concept studies in animal models have demonstrated the possibility of restoring vision using optogenetic techniques, and initial clinical trials are underway, there are still hurdles to pass before such an approach restores naturalistic vision in humans. One limitation is the development of light stimulation devices to activate optogenetic channels in the retina. Here we review recent progress in the design and implementation of optogenetic stimulation devices and outline the corresponding technological challenges. Finally, while most work to date has focused on providing therapy to patients suffering from retinitis pigmentosa, we provide additional insights into strategies for applying optogenetic vision restoration to patients suffering from age-related macular degeneration.
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