期刊
HUMAN & EXPERIMENTAL TOXICOLOGY
卷 39, 期 4, 页码 547-562出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0960327119895559
关键词
Tert-butylhydroquinone; ethanol; nuclear factor erythroid 2-related factor 2; gastric ulcer; nuclear factor kappa-light-chain-enhancer of activated B cells; haeme oxygenase-1; malondialdehyde; cyclooxygenase-2; glutathione; ulcer index
类别
资金
- National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab, India
Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Ethanol-induced GU in animal model resembles the pathophysiology of human ulcer. The present study was designed to investigate the cytoprotective and anti-inflammatory properties of tert-butylhydroquinone (tBHQ), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, against gastric mucosal damage induced by acute exposure of ethanol (5 ml/kg). The intervention of tBHQ (25 and 50 mg/kg, per os (po)) and omeprazole (20 mg/kg, po) was done for 10 consecutive days. Omeprazole was chosen as a standard drug because it is prescribed for the treatment of GU. Pretreatment of tBHQ decreased gastric mucosal lesion, ulcer index, apoptotic cells and lipid peroxidation level induced by ethanol. Furthermore, the intervention of tBHQ increased gastric mucosa integrity, pH, reduced glutathione, collagen and mucus-producing goblet cells. Intervention of tBHQ increased the expression of antioxidant markers such as Nrf2, haeme oxygenase-1 and catalase and decreased the expressions of inflammatory markers such as nuclear factor kappa-light-chain-enhancer of activated B cells and cyclooxygenase-2. The cytoprotective potential of tBHQ against gastric mucosal damage might be due to its ability to enhance cellular antioxidants and anti-inflammatory responses.
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