期刊
GENETIC EPIDEMIOLOGY
卷 44, 期 3, 页码 290-299出版社
WILEY
DOI: 10.1002/gepi.22284
关键词
genome-wide association studies; Mendelian randomization; power calculation; two-stage least squares estimator
Mendelian randomization (MR) study has become a powerful approach to assess the potential causal effect of a risk exposure on an outcome. Most current MR studies are conducted under the two-sample setting by combining summary data from two separate genome-wide association studies (GWAS), with one providing measures on associations between genetic markers and the risk exposure, and the other on associations between genetic markers and the outcome. We develop a power calculation procedure for the general two-sample MR study, allowing for the use of multiple genetic markers, and shared participants between the two GWAS. This procedure requires a few easy-to-interpret parameters and is validated through extensive simulation studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据