期刊
GENES & DEVELOPMENT
卷 34, 期 5-6, 页码 251-253出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.336420.120
关键词
ADP-ribosylation; PARPs; posttranslational modification
资金
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK069710]
- Cancer Prevention and Research Institute of Texas [RP160319, RP190236]
- Cecil H. and Ida Green Center for Reproductive Biology Sciences Endowment
Work on PARPs-a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point the way forward for future advances in the field.
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