期刊
GASTROENTEROLOGY
卷 158, 期 1, 页码 95-110出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2019.08.060
关键词
Glycan; Glycome; Glycomic; Glycosylation; IBD; Liver Disease
资金
- Portuguese Foundation for Science and Technology
- Norte Portugal Regional Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund [NORTE-01-0145-FEDER-000029]
- Fundo Europeu de Desenvolvimento Regional (FEDER) funds through the COMPETE 2020-Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020
- Portuguese Foundation for Science and Technology [POCI-01/0145-FEDER-016601/PTDC/DTP-PIC/0560/2014, POCI-01-0145-FEDER-028772]
- Broad Medical Research Program at the Crohn's and Colitis Foundation of America
- International Organization for the study of Inflammatory Bowel Disease
- Portuguese Group of Study in IBD (GEDII)
- US Department of Defense, US Army Medical Research Acquisition Activity, FY18 Peer Reviewed Medical Research Program Investigator-Initiated Research Award [W81XWH1920053]
- U.S. Department of Defense (DOD) [W81XWH1920053] Funding Source: U.S. Department of Defense (DOD)
Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions. For example, specific glycans regulate T-cell activation, structures, and functions of immunoglobulins; interactions between microbes and immune and epithelial cells; and malignant transformation in the intestine and liver. We review the effects of protein glycosylation in regulation of gastrointestinal and liver functions, and how alterations in glycosylation serve as diagnostic or prognostic factors, or as targets for therapy.
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