期刊
FUTURE MICROBIOLOGY
卷 15, 期 2, 页码 143-157出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2019-0235
关键词
antibiotic; antibiotic resistance; efflux; regulation; RND; structure
类别
资金
- BBSRC [BB/M02623X/1, 1790978, 1898455] Funding Source: UKRI
Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore directly contributing to multidrug resistance. There is also emerging evidence that many other mechanisms of antibiotic resistance rely on the intrinsic resistance conferred by RND efflux. In addition to their role in antibiotic resistance, new information has become available about the natural role of RND pumps including their established role in virulence of many Gram-negative organisms. This review also discusses the recent advances in understanding the regulation and structure of RND efflux pumps.
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