期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 56, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2019.100819
关键词
Neurobiology; Neuroendocrine; Brain; Allostasis; Circadian rhythms
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK119811-01]
- National Science Foundation CAREER Award [1553067]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1553067] Funding Source: National Science Foundation
Stress, primarily processed via the hypothalamic-pituitary-adrenal (HPA) axis, engages biological pathways throughout the brain and body which promote adaptation and survival to changing environmental demands. Adaptation to environmental challenges is compromised when these pathways are no longer functioning optimally. The physiological and behavioral mechanisms through which HPA axis function influences stress adaptation and resilience are not fully elucidated. Our understanding of stress biology and disease must take into account the complex interactions between the endocrine system, neural circuits, and behavioral coping strategies. In addition, further consideration must be taken concerning influences of other aspects of physiology, including the circadian clock which is critical for regulation of daily changes in HPA activity. While adding a layer of complexity, it also offers targets for intervention. Understanding the role of HPA function in mediating these diverse biological responses will lead to important insights about how to bolster successful stress adaptation and promote stress resilience.
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