期刊
FITOTERAPIA
卷 141, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fitote.2019.104466
关键词
Paepalanthus chiquitensis; Curvularia lunata; Spirocyclic lactams; Curvulinic acid; Antibacterial activity
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2016/05480-6, 2015/04899-3, 2013/25432-0, 2018/00187-7]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Curvularia lunata, isolated from the capitula of Paepalanthus chiquitensis (Eriocaulaceae), was cultured in potato dextrose broth (PDB) medium. The ethyl acetate extract yielded two new spirocyclic gamma-lactams (3 and 4), and five known compounds, namely: triticones E (1) and F (2), 5-O-methylcurvillinic acid (5), curvulinic acid (6) and curvulin (7). Their structures were elucidated by spectroscopic analysis and by the comparison with literature data. Besides, a computational study was used to elucidate the absolute configuration of the C - 3' in the compounds (3) and (4). The extract and the compounds (1 and 2), (6) and (7) were assayed against gram positive and gram-negative bacteria and fluconazole-resistant yeast. The triticones (1) and (2) showed good antibacterial activity for Escherichia coli, with a minimum inhibitory concentration of 62.5 mu g/mL.
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