期刊
FIBERS AND POLYMERS
卷 21, 期 2, 页码 252-261出版社
KOREAN FIBER SOC
DOI: 10.1007/s12221-020-9445-3
关键词
Tussah; Silk fibroin; Membrane; Drug release; Artemisinin
资金
- Fundamental Research Funds for the Central Universities [N160504001, N160503001]
- Department of Education of Liaoning Province [ldxy2017002]
- Science and Technology Foundation of Liaoning Province [201602342, 20170520185]
Silk fibroin (SF) aqueous solution was obtained by the degumming and dissolution of tussah silk, and then the obtained solution was chemically cross-linked with sodium alginate (SA) to form composite membrane, which could be used as a carrier for sustained drug release. The mechanical properties and dissolution rate of such composite membrane together with the drug release behavior under different conditions were investigated. A series of structure-tunable composite membranes were prepared through altering the ingredients proportion, the pH value during fabrication, the concentration of Ca2+, and cross-linking time. The drug release behavior of the corresponding drug-loaded composite membrane was elaborate studied using artemisinin as the model drug. It was found that the drug release rate exhibited a decreasing trend with increasing the SF content, the Ca2+ concentration and the cross-linking time of the corresponding composite membrane. Moreover, the drug release behavior exhibited pH sensitivity, and the drug release rate could be promoted under weak alkaline conditions.
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