期刊
FASEB JOURNAL
卷 34, 期 4, 页码 5673-5687出版社
WILEY
DOI: 10.1096/fj.201903044R
关键词
additive manufacture; bioceramic scaffold; electrostatic interaction; foreign-ion doping; pore-wall modification
资金
- National Key Research and Development Program of China [2017YFE0117700]
- National Natural Science Foundation of China [81601881, 81871775, 81772311]
- Basic Public Welfare Research Project of Zhejiang Province [LGF19H180007]
- Medical and Health Research Project of Zhejiang Province [2018KY768]
- Zhejiang Province Bureau of Health [WKJ-ZJ-1711]
- Basic Medical Technology Project of Wenzhou [2018Y1347]
Surface chemistry and mechanical stability determine the osteogenic capability of bone implants. The development of high-strength bioactive scaffolds for in-situ repair of large bone defects is challenging because of the lack of satisfying biomaterials. In this study, highly bioactive Ca-silicate (CSi) bioceramic scaffolds were fabricated by additive manufacturing and then modified for pore-wall reinforcement. Pure CSi scaffolds were fabricated using a direct ink writing technique, and the pore-wall was modified with 0%, 6%, or 10% Mg-doped CSi slurry (CSi, CSi-Mg6, or CSi-Mg10) through electrostatic interaction. Modified CSi@CSi-Mg6 and CSi@CSi-Mg10 scaffolds with over 60% porosity demonstrated an appreciable compressive strength beyond 20 MPa, which was 2-fold higher than that of pure CSi scaffolds. CSi-Mg6 and CSi-Mg10 coating layers were specifically favorable for retarding bio-dissolution and mechanical decay of scaffolds in vitro. In-vivo investigation of critical-size femoral bone defects repair revealed that CSi@CSi-Mg6 and CSi@CSi-Mg10 scaffolds displayed limited biodegradation, accelerated new bone ingrowth (4-12 weeks), and elicited a suitable mechanical response. In contrast, CSi scaffolds exhibited fast biodegradation and retarded new bone regeneration after 8 weeks. Thus, tailoring of the chemical composition of pore-wall struts of CSi scaffolds is beneficial for enhancing the biomechanical properties and bone repair efficacy.
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