期刊
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
卷 46, 期 3, 页码 129-135出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ICL.0000000000000677
关键词
Myopia; Myopia control; Biological mechanisms in myopia; Atropine; Atropine action in myopia
资金
- NMRC Translational and Clinical Research (TCR) Flagship Programme Singapore [R1018]
Myopia is a global problem that is increasing at an epidemic rate in the world. Although the refractive error can be corrected easily, myopes, particularly those with high myopia, are susceptible to potentially blinding eye diseases later in life. Despite a plethora of myopia research, the molecular/cellular mechanisms underlying the development of myopia are not well understood, preventing the search for the most effective pharmacological control. Consequently, several approaches to slowing down myopia progression in the actively growing eyes of children have been underway. So far, atropine, an anticholinergic blocking agent, has been most effective and is used by clinicians in off-label ways for myopia control. Although the exact mechanisms of its action remain elusive and debatable, atropine encompasses a complex interplay with receptors on different ocular tissues at multiple levels and, hence, can be categorized as a shotgun approach to myopia treatment. This review will provide a brief overview of the biological mechanisms implicated in mediating the effects of atropine in myopia control.
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