期刊
BREAST CANCER RESEARCH AND TREATMENT
卷 155, 期 2, 页码 385-393出版社
SPRINGER
DOI: 10.1007/s10549-016-3679-1
关键词
Adolescence; Animal fat; Red meat; Premenopausal; Mammographic density; Breast cancer; Epidemiology
类别
资金
- Breast Cancer Research Foundation
- National Cancer Institute [UM1 CA176726, R01 CA124865, R01 CA67262, R01 CA50385]
- Simeon J. Fortin Charitable Foundation
- Bank of America, N.A.
Adolescence is hypothesized to be a time period of particular susceptibility to breast cancer risk factors. Red meat and fat intake during high school was positively associated with risk of breast cancer among premenopausal women in the Nurses' Health Study II (NHSII). High mammographic density is a strong predictor of breast cancer risk but there is limited research on dietary factors associated with breast density. To test the hypothesis that high intake of animal fat or red meat during adolescence is associated with mammographic density, we analyzed data from premenopausal women in the NHSII. Participants recalled adolescent diet on a high school food frequency questionnaire. We assessed absolute and percent mammographic density on digitized analog film mammograms for 687 premenopausal women with no history of cancer. We used generalized linear regression to quantify associations of adolescent animal fat and red meat intake with mammographic density, adjusting for age, body mass index, and other predictors of mammographic density. Adolescent animal fat intake was significantly positively associated with premenopausal mammographic density, with a mean percent density of 39.2 % in the lowest quartile of adolescent animal fat intake versus 43.1 % in the highest quartile (p trend: 0.03). A non-significant positive association was also observed for adolescent red meat intake (p trend: 0.14). These findings suggest that higher adolescent animal fat intake is weakly associated with percent mammographic density in premenopausal women.
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